inhousefyi
← Back to listings

Sr. Software Engineer, Clinical Software

Personalis, IncFremont, California, United States · Posted 9 days ago
Full-timeEst. 162,500 USD
Apply now

Description

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient. Our highly sensitive assays combine tumor-and-normal profiling with proprietary algorithms to deliver advanced insights even as cancer evolves over time. Our products are designed to detect minimal residual disease (MRD) and recurrence at the earliest timepoints, enable selection of targeted therapies based on ultra-comprehensive genomic profiling, and enhance biomarker strategy for drug development. Personalis is based in Fremont, California.

Summary:

We are seeking a Sr. Software Engineer to design, develop, and maintain our Laboratory Information Management Systems (LIMS). This role is a key contributor to our engineering team, taking ownership of feature development for both existing systems and new cloud-based platforms. You will work with senior engineers to tackle complex problems and deliver high-quality, scalable solutions that power our laboratory operations in a regulated environment.

Onsite: Monday, Tuesday, and Thursday

Responsibilities:

  • Design, develop, test, and maintain software systems and features supporting laboratory operations.
  • Develop and optimize backend services and APIs using Python and/or Java.
  • Implement solutions using a variety of database technologies, including relational and graph databases.
  • Take ownership of deploying and maintaining services in our AWS cloud environment.
  • Actively participate in code reviews, design discussions, and technical documentation to ensure quality and maintainability.
  • Troubleshoot and resolve complex technical issues in development and production environments.
  • Collaborate with cross-functional teams to translate business requirements into robust technical solutions.

Qualifications:

  • B.S. degree in Computer Science, Engineering, or a related technical field.
  • 5 years of professional software development experience.
  • Strong proficiency in at least one programming language such as Python or Java.
  • Proven experience building and deploying applications on AWS.
  • Solid experience with relational databases (e.g., PostgreSQL, MySQL) and developing REST APIs.
  • Experience with version control systems (e.g., Github, Bitbucket) and CI/CD concepts.
  • Excellent problem-solving skills and the ability to work independently on complex tasks.

Preferred:

  • Experience with web frameworks like Flask or FastAPI.
  • Familiarity with modern JavaScript frameworks (e.g., React, Angular, or Vue.js).
  • Experience in the life sciences, healthcare, or another regulated industry.
  • Familiarity with containerization technologies (e.g., Docker).
  • Exposure to graph databases or NoSQL technologies.

What You’ll Gain

  • Opportunity to take ownership of significant features and projects from design to deployment.
  • Deepen your expertise in AWS services and cloud architecture.
  • Gain valuable experience working in a regulated life sciences environment.
  • Clear pathways for career growth into a senior engineering role through mentorship and impactful work.

The hiring range for this position is $150,000 to $175,000 per year, which may factor in various geographic regions. The base pay actually offered will take into account internal equity and also may vary depending on the candidate’s job-related knowledge, skills, and experience among other factors. Our full-time regular positions also include an annual performance-based bonus (or a sales incentive plan) and long-term incentive units (equity) provided as part of our compensation package, in addition to a full range of medical, financial, and/or other benefits, dependent on the level and position offered.

Personalis is an equal opportunity employer and is committed to the full inclusion of all individuals. As part of this commitment, Personalis will ensure that persons with disabilities are provided with reasonable accommodations. If you need an accommodation to participate in the job application or interview process, to perform essential job functions, and/or to receive other benefits and privileges of employment, please let your recruiter know, if/when they contacts you.

Protecting Our Candidates: At Personalis, we value your security. Please note that all official correspondence from our team will come exclusively from @personalis.com email addresses. We will never ask for personal financial information or conduct interviews over text or chat platforms. If you receive a suspicious request, it is likely a scam. We are committed to a safe recruitment experience and actively work with authorities to investigate and prosecute cyber crimes targeting our community.

Personalis is an Equal Opportunity Employer/Minorities/Females/Veterans/Disabilities. Personalis offers a competitive compensation package and benefits including medical, dental, vision, 401(k) match, ESPP, tuition reimbursement, sick/vacation time, commuter benefits/ EV charging stations, onsite gym, and wellness benefits. (For US only, benefits in other countries may vary.)

#LI-KK1 #LI-Hybrid

Similar jobs

Personalis, IncFremont, California, United States

Est. 120,500 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Personalis, IncFremont, California, United States

Est. 150,000 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Personalis, IncFremont, California, United States

Est. 69,450 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Personalis, IncFremont, California, United States

Est. 100,000 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Personalis, IncFremont, California, United States

Est. 124,800 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Personalis, IncFremont, California, United States

Est. 100,000 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Personalis, IncFremont, California, United States

Est. 187,500 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Personalis, IncFremont, California, United States

Est. 181,440 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Personalis, IncFremont, California, United States

Est. 49,920 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
BillionToOneMenlo Park, California, United States

Est. 34,320 USD

A Rare Opportunity to Shape the Future of Genomics Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq w…

Full-time
VeracyteSan Diego, California, United States

Est. 258,000 USD

At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees…

Full-time
FreenomeRemote

Est. 194,625 USD

About this opportunity: At Freenome, we are seeking a Senior Software Engineer II to join our innovative Engineering team. The ideal candidate is an experienced backend engineer with a strong background in developing sca…

Full-timeRemote
Personalis, IncFremont, California, United States

Est. 52,480 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Personalis, IncFremont, California, United States

Est. 93,360 USD

At Personalis, we are transforming the active management of cancer through breakthrough personalized testing. We aim to drive a new paradigm for cancer management, guiding care from biopsy through the life of the patient…

Full-time
Precision for MedicineFrederick, Maryland, United States

Est. 254,000 USD

Position Summary: The Senior Director, Companion Diagnostics (sitting onsite in Frederick, MD) will be responsible for overseeing the laboratory activities for teams focused on supporting both commercially approved CDx s…

Full-time
Precision Medicine GroupFrederick, Maryland, United States

Est. 254,000 USD

Position Summary: The Senior Director, Companion Diagnostics (sitting onsite in Frederick, MD) will be responsible for overseeing the laboratory activities for teams focused on supporting both commercially approved CDx s…

Full-time
FreenomeBrisbane, California, United States

Est. 140,000 USD

About this opportunity: At Freenome, we are seeking a Senior Development Scientist I to help grow the Freenome Genomics Late Development team. You will develop, optimize, verify, and validate clinical-grade assay technol…

Full-time
Isomorphic LabsCambridge, Massachusetts, United States

Est. 250,000 USD

Isomorphic Labs is applying frontier AI to help unlock deeper scientific insights, faster breakthroughs, and life-changing medicines with an ambition to solve all disease. The future is coming. A future enabled and enric…

Full-time
Manager, LIMS25 days ago
VeracyteSan Diego, California, United States

Est. 157,000 USD

At Veracyte, we offer exciting career opportunities for those interested in joining a pioneering team that is committed to transforming cancer care for patients across the globe. Working at Veracyte enables our employees…

Full-time
Precision Medicine GroupFrederick, Maryland, United States

Est. 254,000 USD

Position Summary: The Executive Director / Site Head of Precision for Medicine (located onsite in Frederick, MD) will be responsible to oversee the laboratory operations across 3 different functional groups in Frederick,…

Full-time

Est. 152,500 USD

Rapidly Growing Life Sciences Technology Company Ultima Genomics is a rapidly growing company that is developing ground-breaking genomics technologies. Our mission is to continuously drive the scale of genomic informatio…

Full-timeRemote
FreenomeRemote

Est. 194,625 USD

About this opportunity: At Freenome we are seeking a Senior Software Engineer to grow our Platform team. This is an opportunity to join a stellar group of engineers with the mission to enable scientific innovation, cross…

Full-timeRemote
Ultima GenomicsFremont, California, United States

Est. 77,080 USD

Rapidly Growing Life Sciences Technology Company Ultima Genomics is a rapidly growing company that is developing ground-breaking genomics technologies. Our mission is to continuously drive the scale of genomic informatio…

Full-time
Ultima GenomicsFremont, California, United States

Est. 170,000 USD

Rapidly Growing Life Sciences Technology Company Ultima Genomics is a rapidly growing company that is developing ground-breaking genomics technologies. Our mission is to continuously drive the scale of genomic informatio…

Full-time
Precision for MedicineFrederick, Maryland, United States

Est. 254,000 USD

Position Summary: The Executive Director / Site Head of Precision for Medicine (located onsite in Frederick, MD) will be responsible to oversee the laboratory operations across 3 different functional groups in Frederick,…

Full-time
FreenomeBrisbane, California, United States

Est. 85,000 USD

About this opportunity: At Freenome, we are seeking a Senior Research Associate to help grow our Genomics Assay Development team. At Freenome, you will help develop the assay technologies used to analyze patient samples…

Full-time
BillionToOneMenlo Park, California, United States

Est. 156,194 USD

A Rare Opportunity to Shape the Future of Genomics Join a team of brilliant, passionate innovators determined to transform healthcare. At BillionToOne, we've built a category-defining, publicly traded company on Nasdaq w…

Full-time

We’re expanding our data engineering capabilities across Mexico, Brazil, Argentina, Colombia, Chile, and Peru, and we’re hiring a Senior Clinical Data Engineer to help build the foundation of this new regional function.…

Full-timeRemote

We’re expanding our data engineering capabilities across Mexico, Brazil, Argentina, Colombia, Chile, and Peru, and we’re hiring a Senior Clinical Data Engineer to help build the foundation of this new regional function.…

Full-timeRemote

Precision for Medicine is growing and we are looking for an exceptional Principal Database Programmer to join our European team. This is a full-time, permanent position that can be covered fully remotely from our Europea…

Full-timeRemote