Director, Program Management
Summit TherapeuticsPalo Alto, California, United States · Posted 9 days agoDescription
About Summit:
Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence.
Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including:
Non-small Cell Lung Cancer (NSCLC)
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HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI.
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HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC.
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HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC.
Colorectal Cancer (CRC)
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HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy.
Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland.
Our Mission
To build a viable long-lasting health care organization that assumes full responsibility for designing, developing, trial enrollment, regulatory approval and commercializing patient, physician, caregiver, payor, and societal friendly medicinal therapy intended to improve quality of life, increase potential duration of life and resolve serious medical healthcare needs. We will accomplish this by building a team of world-class scientists and business administrators that apply themselves to this mission.
We have in-licensed Ivonescimab (PD-1/VEGF Bispecific Antibody, SMT112), which is a novel, potential first-in-class investigational bispecific antibody combining the effects of immunotherapy via a blockade of PD-1 with the anti-angiogenesis effects associated with blocking VEGF into a single molecule. We have ongoing phase-III clinical studies in multiple indications including NSCLC and CRC.
Overview
The Director of Program Management provides strategic and operational leadership across multiple development programs, driving alignment between Research, Development, Business Strategy, Manufacturing, and execution. This role plays a critical part in advancing collaboration programs across the portfolio and enabling long-term value creation from development through regulatory approval.
The Director serves as the primary point of contact for key programs to executive leadership, ensures disciplined program governance, and strengthens the Program Management function as the organization scales. This position reports to the VP, Program Management and may have people leadership responsibility.
Role and Responsibilities
Strategic Program Leadership
- Responsible for overall execution of multiple programs to deliver on program objectives and maximize value.
- Partner with executive leadership on program, strategy,
- Define and oversee major milestones, decision points, objectives, and inflection points across programs
- Lead scenario planning, trade-off analyses, and decision frameworks to support executive decision-making
- Ensure alignment across Development, Regulatory, Manufacturing, and Corporate Strategy
Cross-Functional & Executive Leadership
- Lead and integrate complex cross-functional workstreams across Research, Development, Regulatory, and Manufacturing
- Facilitate effective decision-making and accountability across global teams and external partners, in collaboration with Alliance Management.
- Present clear insights, recommendations, and program status to C-suite and senior leadership
- Mentor and develop Program Managers and strengthen organizational capability
Program Execution & Governance
- Oversee end-to-end program execution, including activation of new indications post–Go decision
- Ensure consistent application of program management standards, dashboards, and governance models
- Chair timely, efficient, and action-oriented team meetings to coordinate operations and communications.
- Review and validate integrated program plans, timelines, and metrics for accuracy and strategic alignment
- Represent Program Management on senior governance forums and key internal or external teams
Timelines & Scenario Planning
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